This channel, known as the inward rectifier potassium current (IK1), is open during diastole. In order to avoid spontaneous delayed following depolarization during Phase 4 of the action potential, it serves as a repolarization reserve.
Voltage clamp displays inward rectifier potassium current(positive charge entering the cell) as a downward deflection and outward current (positive charge leaving the cell) as an upward deflection. Inwardly rectifying K+ channels support the entry of positively charged K+ ions into the cell at membrane potentials that are negative to potassium's reversal potential, causing the membrane potential to return to its resting potential. Figure 1 illustrates this: inward current flows when the membrane potential is clamped negatively to the channel's resting potential (for example, -60 mV).
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