while comparing the amino acid sequences of many different gpcrs, you notice the presence of conserved serine and threonine amino acids on the same cytosolic region of each receptor. you change the dna sequence so that all of the conserved serine and threonine amino acids in the cytosolic region are converted to glutamic acid. which of the following effects would you most likely see when cells expressing this modified gpcr are exposed to ligand compared to your control cells that do not express the modified gpcr? group of answer choices a. Cells expressing the modified GPCR will display a reduced response more quickly than control cells.
b. The modified GPCR will be recycled to the cell surface more rapidly than the modified GPCR.
c. The modified GPCR will undergo endocytosis sooner than the unmodified GPCR.
d. The modified GPCR will undergo endocytosis sooner and cells expressing the modified GPCR will display a reduced response more quickly than control cells.
e. Cells expressing the modified GPCR will display a sustained response compared to the control cells.

Question

30-11-2022
Biology

contestada

while comparing the amino acid sequences of many different gpcrs, you notice the presence of conserved serine and threonine amino acids on the same cytosolic region of each receptor. you change the dna sequence so that all of the conserved serine and threonine amino acids in the cytosolic region are converted to glutamic acid. which of the following effects would you most likely see when cells expressing this modified gpcr are exposed to ligand compared to your control cells that do not express the modified gpcr? group of answer choices a. Cells expressing the modified GPCR will display a reduced response more quickly than control cells.
b. The modified GPCR will be recycled to the cell surface more rapidly than the modified GPCR.
c. The modified GPCR will undergo endocytosis sooner than the unmodified GPCR.
d. The modified GPCR will undergo endocytosis sooner and cells expressing the modified GPCR will display a reduced response more quickly than control cells.
e. Cells expressing the modified GPCR will display a sustained response compared to the control cells.

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abhinavjh321 abhinavjh321 · Answer 1 · 2022-12-03T06:57:13+01:00

Cells that express the mutant GPCR will have a persistent response. The bulk of intracellular reactions to inputs are mediated by G protein-coupled receptors (GPCRs), the exchange activation of GTP.

The production of intracellular messengers controls the activation of MAPKs by GPCRs as well. The second messenger pathways AC/cAMP and PLC/PKC are activated by GPCR activity. Raf-1-activated ERK activity may be inhibited by the activation of the RAP-1/B-Raf/ERK pathways by cAMP, either directly or through PKA. The precise pattern of the processes involved in the desensitization of GPCRs depends on the GPCR subtype and may potentially include intracellular context dependent.

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