Which of the following studies is linked most directly to the establishment of the National Research Act in 1974 and ultimately to the Belmont Report and Federal regulations for human subject protectionThe Public Health Service Tuskegee Study of Untreated Syphilis in the Negro Male

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The correct answer is study titled "The Public Health Service Tuskegee Study of Untreated Syphilis in the Negro Male"

Between 1932 and 1972, the U.S. Public Health Service (USPHS) Syphilis Study in Tuskegee tracked the progression of the disease naturally. Researchers failed not get patients' informed consent for the trial and did not provide treatment, even after it was publicly available. The goal of the study was to document the syphilis natural history in Black individuals. The Tuskegee Study of Untreated Syphilis in the Negro Male was the name of the investigation. There were no effective treatments for the condition at the time the study was started.

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