Respuesta :
Acetyl-CoA indicates that the conversion of fat to carbs is necessary. Acetyl-CoA carboxylase accumulation indicates a lack of citrate. NADH is produced for energy when pyruvate carboxylase is activated by acetyl-CoA.
Why is it logical that acetyl-CoA would cause pyruvate carboxylase to be activated?
Acetyl-CoA selectively activates pyruvate carboxylase. When acetyl-CoA concentrations are high, organisms use pyruvate carboxylase to divert pyruvate from the TCA cycle because acetyl-CoA is a crucial metabolite in the TCA cycle that generates a lot of energy.
How does pyruvate carboxylase become activated by acetyl-CoA?
The production of more oxaloacetate is triggered by an excess of mitochondrial acetyl-CoA. When lipolysis is induced, for instance, intramitochondrial acetyl-CoA levels rise, allosterically activating pyruvate carboxylase to produce more oxaloacetate for gluconeogenesis.
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