what characteristic of dna allows methylation patterns to be maintained throuh replication and cell devision

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dianaskye7141 dianaskye7141

30-11-2022
Biology

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what characteristic of dna allows methylation patterns to be maintained throuh replication and cell devision

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charithran8975 charithran8975 · Answer 1 · 2022-12-02T18:48:55+01:00

Maintenance of such a methylation pattern in DNA during replication is mediated by DNA nucleotide methyltransferase 1 (DNMT1) [11], which methylates newly synthesized CpG sequences.

Depending on the methylation status of the template strand, inheritance of DNA methylation through replication occurs easily and rapidly, as newly replicated hypomethylated DNA serves to recruit housekeeping DNA methylases to restore DNA methylation in the newly replicated strand of DNA. Cell division and epigenetic inheritance: DNA replicates in a semi-conservative way. Various DNA replication machines preserve genetic and epigenetic information. DNA methylation patterns are believed to be maintained through mitosis by DNA methyltransferase. Most DNA methylation is essential for normal development and plays a very important role in a number of key processes, including genomic imprinting, X chromosome inactivation and repeat deletion. transposition and transcription elements and, when dysregulated, contributes to diseases such as cancer.

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