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A relatively consistent rate of evolutionary change in the virus.

What are the two characteristics that the molecular clock for HIV is based on?

  • The existence of, and how to describe, a molecular clock in evolving HIV-1 populations, as well as the link between nucleotide changes and time.
  • In order to achieve this, we looked at a special collection of samples for which the evolutionary history is completely known.
  • This allowed us to directly correlate the genetic distances between the samples' separation times.
  • The study's findings could lead to two significant conclusions.
  • First, we demonstrate how the idea of a molecular clock is compatible with the evolution of HIV-1.
  • Second, we show that there is a large genetic distance at a time of no divergence; this conclusion is dependent on the pretransmission delay.

  1. A relatively consistent rate of evolutionary change in the virus
  2. Multiple samples of the virus taken in different years
  3. RNA nucleotide sequence data from the virus
  4. None of the listed responses are correct.

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