Density of population does not of itself determine the ease with which infection spreads through a population. Problems tend to arise primarily when populations become overcrowding.
Overcrowded cities or Densely populated areas of cities can potentially serve as breeding grounds for infectious agents, which may facilitate their evolution, particularly in the case of viruses and bacteria. Since the pathogen of a disease needs to be introduced into the human population and then subsequently spread and maintain itself in the population, a large human population size favors the spread and perpetuation of diseases.
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