Raphael had to make a full-size cartoon for that part of the painting.
Painting is the application of paint, pigment, color, or another substance to a solid surface. The medium is often applied to the base with a brush, but knives, sponges, and airbrushes can also be employed. Painting in art refers to both the act and the result of the action.
Sizing is the initial step in preparing the painting support. It is not a coating or separate layer, but rather a layer that penetrates into the pores of the support fibers, sealing them to prevent the paint from coming into direct touch with them and making them less absorbent.
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