Respuesta :
Insulator sequences are the Protein-binding sequences that direct enhancers to interact with the intended promoter block communication between enhancers and another promoters.
What are Insulator Sequences?
Insulators are DNA sequence elements that can serve in some cases as barriers to protect a gene against the encroachment of adjacent inactive condensed chromatin.
Some insulators also can act as blocking elements to protect against the activating influence of distal enhancers associated with other genes.
What is an Insulator Binding Protein?
Insulators are DNA-protein complexes experimentally defined by their ability to block enhancer-promoter interactions and/or serve as barriers against the spreading of the silencing effects of heterochromatin.
Function-
- Insulators contain clustered binding sites for sequence specific DNA-binding proteins and mediate intra- and inter-chromosomal interactions.
- Insulators function either as an enhancer-blocker or a barrier, or both.
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