Answer:
Kinase inhibitor has low specificity
Explanation:
In humans, Bruton's tyrosine kinase (BTK) is a protein tyrosine kinase encoded by the BTK gene, which plays key functions in the mechanisms of development, differentiation, and signaling of B-lymphocytes. In the last years, many BTK inhibitor drugs have been developed, including Ibrutinib, Acalabrutinib and Zanubrutinib. It has been shown that kinase inhibitors may have low specificity because these molecules exhibit a high conservation level in the ATP binding pocket, which is known as 'inhibitor promiscuity'.
