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The difference between mixtures and substances is that substances have a definite composition that mixtures, as well as how they are homogeneous, and have elements/compounds. On the other hand, mixtures don't have definite composition and can also be homo/heterogeneous.
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Mixtures are physically combined structures that can be separated into their original components. A chemical substance is composed of one type of atom or molecule. A mixture is composed of different types of atoms or molecules that are not chemically bonded.
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